Biology of Cancer Study Guide - 1184 Words

Cancer Biology Section 1 Study questions What is lifetime risk of getting cancer for men and women in US? Male-1:2 Female-1:3 Which cancer are men mostly likely to get in the US? Women? Male-Prostate Female-Breast Which cancers are the most deadly and least deadly (US)? Most deadly- Lung Least deadly- non-melanoma skin cancer Name the cell-types that define carcinomas, sarcomas, lymphomas, and leukemia’s. Which type is most common? Carcinomas- glands, organs and tissues, arise from epithelial cell lining external and internal body surfaces; most common cancer Sarcomas- connective tissues (fat, bone, muscle) Lymphomas- lymph nodes Leukemias- bloodstream. Describe and identify normal tissues, tissues undergoing†¦show more content†¦those who inherit hereditary nonpolyposis colon cancer (HNPCC) have higher likelihood of developing cancer Other types of DNA Damage Some chemicals can induce the loss of bases Some chemicals can induce the modification of bases: Note: Conversion of C to U will result in a C:G to A:T mutation after replication UV radiation induced pyrimidine (Mostly T) dimer formation. Explain the difference between the two classes of carcinogens: promoters and mutagens, and how they sometimes work together to increase the risk of cancer development. What is a complete carcinogen? How is the Ames test used? Carcinogens: SubstancesShow MoreRelatedNegative Effects Of Thalidomide1475 Words   |  6 PagesPR, 3 (15 %) SD and 12 (60 %) PD was noted. Although there were some responses observed, the authors suggested that despite some responses observed with this therapy, rosiglitazone did not result in clinically significant response [36]. In another study including more patients, increases in radioiodine uptake after[6 weeks of pretreatment with up to 8 mg of rosiglitazone were observed in 26 % of the patients. However, post-therapy decreases in TG levels were only noted in 17 % of cases [37]. But itRead MoreEssay On Engineering E. Coli Cells1019 Words   |  5 PagesObjective: This study aims to use synthetic biology methods to engineer E. coli cells to target, invade, and deliver therapeutic agents to breast cancer tumor growths. Non-pathogentic E. coli strains will be engineered to express an artificial plasmid which allows for eukaryotic cell invasion. Bacterial cells will be further programmed with an AND logic gate allowing for specificity for breast cancer cell invasion. Finally, E. coli cells will express a dual plasmid system to control population growthRead MoreThe Assessment Of Nuclear Atypia, Mitotic Count And Lymphocyte Infiltration777 Words   |  4 Pagespathologists. This significant inter- and intra-observer discordance can have a negative impact on clinical care, as these factors can be used to guide clinical decisions today (e.g., use of chemotherapy in high-grade breast cancer) and may have an even larger impact on clinical decisio ns in the future (e.g., assessment of tumor infiltrating lymphocytes to guide the use of immunotherapies). Thus, the accurate pathological diagnosis represents a critical decision-point in clinical medicine, and there wouldRead MoreThe Four Main Determinants Of Health1702 Words   |  7 Pagesperson, so it is very important for healthcare workers, especially nurses, to know the causes, affects, responses, and symptoms that occur in unhealthy and healthy lifestyles. This paper will outline and discuss the four main determinants of health; biology and genetics, individual behavior, physical environment, and social circumstances, and how healthcare providers such as nurses can use this knowledge to promote health. By having a better understanding of healthy lifestyles, and the factors that contributeRead MoreGenetic Research : Genetic Researcher1253 Words   |  6 Pages Introduction: My topic for the paper is study on Genetic Researchers. A genetic researcher or a genetic scientist analyzes hereditary characteristics to develop new pharmaceutical and agricultural products. They also work in clinical settings, as counselors for genetic diseases or physicians administering genetic treatments. A genetic researcher also alters genes in order to improve the biological capabilities of humans, plants and animals. In this field, the main goal is to help people lead qualityRead MoreCONCLUSIONS AND FUTURE DIRECTIONS This thesis includes studies focusing on four of the ten600 Words   |  3 PagesCONCLUSIONS AND FUTURE DIRECTIONS This thesis includes studies focusing on four of the ten recently discovered human polyomaviruses: MCPyV, KIPyV, WUPyV, and TSPyV, with respect to determination of their molecular and serological epidemiology, transmition route, and latency site and in finding any association between these novel viruses and diseases. Despite understanding many clinical and biological aspects, future studies may aim at addressing additional issues. Clearly, the development of cellRead MoreEssay about Breast Cancer836 Words   |  4 PagesBreast cancer is one of the most widespread cancers among women worldwide. In the US, it is the most common, and the leading cause of cancer related deaths among women between 45 – 64 years of age (Clegg et al., 2002; Ward et al., 2008). Early detection and improved treatment procedures have resulted in gradual decline in the number of deaths caused by the disease since 1990. Nevertheless, in 2009, the estimated death toll for the disease was 40,170 (American Cancer Society, 2009). The gravityRead MoreThe Importance Of Techniques In Research1596 Words   |  7 Pagesinvestigations and the data is questionable, the conclusions drawn will be invalid(L Gordis, 1979). Therefore, epidemiologists pay attention to their measures and they do this by whenever possible choosing measures that have been used effectively in previous studies to measure both suspected risk factors and disease out comes. In some cases, the validity and reliability of the instruments are known thereby allowing to some extent, the assessment of, and even correction for, possible bias and misclassificationRead MoreGenes And Their Effects On Gene Editing Essay1428 Words   |  6 PagesGene editing is one of the most researched fields of molecular biology, as manipulated genes deem possible studying the specific genes and their effects. In the past, there were several attempts to manipulate gene function, including homologous recombination, RNA interference (RNAi), zinc-finger nucleases (ZFNs) and transcription-activator like effector nucleases (TALENs). These past approaches are expensive and time-consuming to engineer as opposed to Crispr Cas9, limiting their widespread useRead MoreWhat Is Breast Cancer?937 Words   |  4 PagesBreast cancer is one of the most common cancers and the second leading cause of cancer-related death among women in the United States. Up to 6% of breast cancers are a dvanced or metastatic at the time of diagnosis, requiring chemotherapy1, 2. Aberrant, accelerated growth is a hallmark of cancer3, including breast cancer. The rapid expansion of treatments targeted to aberrant cell growth – for example, cell cycle targeted chemotherapies for the treatment of metastatic breast cancer – allows for precise